相关实验视频

Updated: Sep 12, 2025

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

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组织素甲基转移酶DOT1L与LSD1合作,控制爆发期MPN中的细胞分裂

Karl Kapahnke1,2, Thomas Plenge1, Tabea Klaus1

  • 1Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

Leukemia
|August 9, 2025
PubMed
概括

针对DOT1L,而不仅仅是其酶活性,增强了LSD1抑制剂对先进骨髓增殖性新生瘤 (MPN) 的疗效. 这种方法可以改善MPN爆发期的治疗方法,这是疾病的一个具有挑战性的阶段.

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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis08:33

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Direct Measurement of KDM1A Target Engagement Using Chemoprobe-based Immunoassays11:17

Direct Measurement of KDM1A Target Engagement Using Chemoprobe-based Immunoassays

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