3D打印的核心外片用于有效的AT-MSC分泌物的口服输送,用于炎症性肠病治疗
Elena Munoz-Perez1,2, Edorta Santos-Vizcaino1,3,2, Alvaro Goyanes4,5
1NanoBioCel Research Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, Vitoria-Gasteiz, 01006, Spain.
研究人员开发了3D打印的平板电脑,用于口服输送中细胞流体细胞 (MSCs) 的秘密体. 这种新的方法保护治疗性蛋白质,为炎症性肠病 (IBD) 治疗提供了患者友好的解决方案.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 胃肠病学 胃肠病学
背景情况:
- 炎症性肠病 (IBD) 的管理是复杂的,促使人们对新型疗法的研究.
- 介质细胞干细胞 (MSCs) 显示出免疫调节潜力,但直接施用面临短半衰期和排斥等挑战.
- MSCs secretome提供了一个无细胞的替代方案,但口服交付和个性化仍然是重大障碍.
研究的目的:
- 开发一种新的口服输送系统,用于脂肪组织衍生的MSC分泌体 (AT-S).
- 利用3D打印技术制造能够保护秘密体的核心片.
- 解决IBD治疗的秘密稳定性,可管理性和口服管理方面的挑战.
主要方法:
- 化MSC分泌基因组 (LpAT-S),以提高稳定性和可管理性.
- 开发3D打印的核心外平板电脑,用于封装冷解型AT-S.
- 在体外评估3D打印系统保护分泌蛋白质免受胃部降解的能力.
主要成果:
- 淋化AT-S (LpAT-S) 显示稳定性和操控性得到改善.
- 这些3D打印的核心外片成功地保护了从模拟的胃状况中分泌的蛋白质.
- 这项技术使MSC秘密疗法的口服管理成为可能.
结论:
- 3D打印提供了一种可行且创新的解决方案,用于口服MSC秘密的传递.
- 这种方法克服了与基于秘密的疗法相关的关键技术挑战.
- 开发的系统与用于个性化IBD治疗的精准医学原则保持一致.
更多相关视频
07:10Author Spotlight: Development and Application of a Canine IBD Gut-on-a-Chip Model for 3D Intestinal Morphogenesis Studies
Published on: February 9, 2024
09:17Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
相关概念视频
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Drugs for Treatment of Ulcerative Colitis in IBD
Drug Delivery: Enteral Route
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
