Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Role of Amygdala in Memory01:16

Role of Amygdala in Memory

397
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
397
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

3.9K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
3.9K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

2.6K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.6K
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

96.7K
Overview
96.7K
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

3.3K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.3K
Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

2.7K
The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
2.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Arc Capsids Facilitate the Transfer of Muscleblind.

bioRxiv : the preprint server for biology·2026
Same author

Suppression of binge alcohol drinking by an inhibitory neuronal ensemble in the mouse medial orbitofrontal cortex.

Nature neuroscience·2025
Same author

Dopamine transporter endocytic trafficking: Neuronal mechanisms and potential impact on DA-dependent behaviors.

Journal of neurochemistry·2024
Same author

Interpeduncular GABAergic neuron function controls threat processing and innate defensive adaptive learning.

Research square·2024
Same author

Prompting social investigation.

eLife·2024
Same author

Dopamine control of social novelty preference is constrained by an interpeduncular-tegmentum circuit.

Nature communications·2024

相关实验视频

Updated: Sep 12, 2025

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices
11:13

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices

Published on: April 5, 2016

16.1K

跨脚的GABAergic神经元功能控制威胁处理和天生的防御性适应性学习.

Elora W Williams1,2, Leshia Snively1, Benjamin R O'Meara1,2

  • 1Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.

Molecular psychiatry
|August 9, 2025
PubMed
概括
此摘要是机器生成的。

当威胁不真实时,小鼠学会了减少防御行为. 这种自适应性防御性学习涉及中脑关核 (IPN) 和其投影,提供了对焦虑症的洞察力.

更多相关视频

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning
11:02

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning

Published on: August 21, 2015

23.7K
Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala
09:49

Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala

Published on: April 15, 2016

11.1K

相关实验视频

Last Updated: Sep 12, 2025

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices
11:13

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices

Published on: April 5, 2016

16.1K
Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning
11:02

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning

Published on: August 21, 2015

23.7K
Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala
09:49

Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala

Published on: April 15, 2016

11.1K

科学领域:

  • 神经科学是一个神经科学.
  • 行为生物学 行为生物学
  • 计算神经科学是一种神经科学.

背景情况:

  • 防御性行为对于生存至关重要,但在没有威胁时调整这些反应对幸福至关重要.
  • 适应性防御行为失调与神经精神疾病,如焦虑症有关.
  • 在反复出现非危险威胁后,适应性防御性学习背后的机制在很大程度上仍未被探索.

研究的目的:

  • 在小鼠中使用视觉迫在眉的刺激 (VLS) 范式研究先天威胁处理和自适应防御学习的神经机制.
  • 为了确定大脑区域和电路参与调整防御行为,当威胁是可预测和非危险的.
  • 探索跨脚核 (IPN) 在调节防御反应和学习中的作用.

主要方法:

  • 在小鼠中利用视觉迫在眉的刺激 (VLS) 范式来引起先天的威胁反应.
  • 采用纤维光度和光遗传学操纵来记录和控制神经活动.
  • 进行功能电路映射,以确定涉及防御性学习的特定神经通路.

主要成果:

  • 重复暴露于VLS导致结和寻找庇护的减少,探索性行为增加,表明适应性学习.
  • 天生的自适应防御性学习与跨关节核 (IPN) 的招募减少有关.
  • 特定的IPN投射到后背体核被确定为关闭这种防御性学习的关键. 发现,表达索马托斯塔丁的IPN神经元的一个亚群编码避开信号.

结论:

  • 这项研究确定了一些关键的行为变化,这些变化表明了先天的防御反应和适应性学习.
  • 涉及IPN及其投影的特定神经回路调节威胁处理和防御性行为适应.
  • 了解这种电路为焦虑和恐惧相关疾病的神经生物学提供了关键的见解.