尿病原体在糖尿病患者中的抗微生物耐药性
Anas H Abu-Humaidan1, Yazeed Y Alajlouni2, Amin Y Alajlouni3
1Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman, 11942, Jordan. A.abuhumaidan@ju.edu.jo.
BMC infectious diseases
|August 9, 2025
概括
患有尿路感染的糖尿病 (DM) 患者在尿病原体中表现出抗菌素耐药性 (AMR) 的增加. 具体来说,DM患者对尼托福兰的耐药性更高,这表明DM是特定AMR模式的风险因素.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 糖尿病研究研究 糖尿病研究
背景情况:
- 患有糖尿病 (DM) 的患者有更高的尿路感染率.
- 泌尿病原体抗菌素耐药性 (AMR) 在尿路感染管理中越来越令人担忧.
- 这项研究调查了尿病原体中的AMR模式,来自患有尿路感染的糖尿病患者.
研究的目的:
- 评估和比较泌尿病原体的抗微生物耐药性 (AMR) 概况.
- 为了确定从糖尿病患者 (DM) 中分离出来的泌尿病原体是否与非糖尿病患者相比表现出更大的AMR.
- 确定DM和特定抗生素耐药性之间的潜在关联.
主要方法:
- 从2020年12月到2021年1月,进行了一项横截面的多中心研究.
- 成年患有尿路感染症状和阳性尿培养的患者被分为无并发性尿路感染 (G1),没有DM的复杂性尿路感染 (G2) 和DM的复杂性尿路感染 (G3).
- 统计分析包括克鲁斯卡尔-瓦利斯,恩的多重比较和费舍尔的精确测试来分析AMR数据.
主要成果:
- 来自复杂的尿路感染组 (G2,G3) 的大肠杆菌对多种抗生素和类别的耐药性比不复杂的尿路感染 (G1) 更高.
- 多抗药性大肠杆菌的流行率为30.5% (G1),61.8% (G2) 和59.0% (G3).
- 来自DM患者的大肠杆菌 (G3) 与非DM复杂性尿路感染患者 (G2) 相比 (34.3%) 具有显著更高的耐药性 (10.2%,p < 0.001).
结论:
- 糖尿病可能与尿路病原体对酸黄的耐药性增加有关.
- 通过DM等风险因素对尿路感染患者进行分层,可能会改善经验治疗并减少AMR.
- 需要进一步的研究来了解DM和AMR模式之间的具体机制.
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