药剂师主导的降低处方,以提高骨骨折的老年患者的药物安全性
Tingting Hu1, Yu Wang1, Renzheng Wu1
1Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, China.
BMC geriatrics
|August 9, 2025
概括
药剂师主导的抑郁处方干预显著降低了老年关节骨折患者的不良药物反应 (ADR) 和潜在不适当的药物 (PIM). 这种方法优化了药物治疗,提高了患者的安全性和改善了临床结果.
科学领域:
- 老年医学 老年医学
- 临床药房 临床药房
- 患者安全 患者安全
背景情况:
- 患有关节骨折的老年人由于多病症和多药性而面临药物不良反应 (ADR) 的高风险.
- 潜在不合适的药物 (PIMs) 导致该群体患者安全风险增加.
- 通过干预措施优化药物治疗对于改善老年关节骨折患者的治疗结果至关重要.
研究的目的:
- 评估临床药剂师主导干预措施在减少部骨折的老年住院患者中不良反应的有效性.
- 评估药剂师干预对PIM和药物相互作用 (DDI) 的患病率的影响.
主要方法:
- 一项横截面研究包括75岁以上因关节骨折住院的患者.
- 临床药剂师主导的药物审查确定了PIM并建议尽量减少药物使用.
- 在PIM和DDI评估中,分别使用了2023年AGS/Beers标准和Medscape标准. 监测了ADR的数量和质量.
主要成果:
- 与对照组相比,干预组的处方药 (8.89对11.38) 和PIM (1.11对1.82) 显著减少.
- 干预组 (17.14%) 与对照组 (69.01%) 的副作用发生率明显较低.
- 功能衰竭是ADR的独立风险因素,而药剂师的干预显著降低了ADR发生率 (OR:0.14).
结论:
- 临床药剂师主导的抑郁处方干预措施有效地减少了老年关节骨折患者的PIM和ADR.
- 这种干预策略显著减少了处方药的数量,并提高了患者的安全.
- 通过药剂师的参与优化药物治疗方案对于这个脆弱的患者群体至关重要.
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