相关实验视频
Updated: Sep 12, 2025
10:37
Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
36.0K
CDH3通过推动表皮细胞-介质细胞过渡进展,促进肺腺癌的进展
Wenlin Gong1,2,3, Fushan Gao1,3, Haihua He1,3
1Department of Thoracic Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Journal of translational medicine
|August 9, 2025
概括
卡德林-3 (CDH3) 通过促进瘤生长和免疫抑制,驱动肺腺癌 (LUAD) 的进展. 向CDH3可能会改善LUAD诊断,预后和免疫治疗反应.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 卡德林-3 (CDH3) 涉及癌症,但其在肺腺癌 (LUAD) 中的特定作用尚未完全理解.
- 了解LUAD中CDH3的机制对于开发向疗法至关重要.
研究的目的:
- 研究CDH3在肺腺癌 (LUAD) 中的生物学作用和机制.
- 评估CDH3与患者的治疗结果和免疫治疗反应的关联.
主要方法:
- 分析了LUAD组织中的CDH3表达,并将其与患者的存活率和临床数据相关联.
- 利用生物信息学,免疫评分,单细胞分析和体外/体内实验来探索CDH3的功能关联.
- 评估了CDH3与表皮细胞-介质细胞过渡 (EMT),炎症,糖解,缺氧和与瘤相关的巨细胞的关系.
主要成果:
- 在LUAD组织中增加的CDH3表达与较差的生存率相关,并促进了EMT,炎症,糖解,缺氧和免疫抑制.
- 高CDH3表达与瘤相关的巨细胞透率增加和抗瘤免疫力受损有关.
- 在实验室中,CDH3 Knockdown抑制了LUAD细胞的增殖,迁移,糖解和EMT,并在体内抑制了瘤的生长.
结论:
- CDH3促进LUAD的进展,转移和免疫逃避.
- CDH3 作为一个潜在的 LUAD 诊断/预后生物标志物.
- CDH3代表了增强LUAD免疫疗法的有前途的治疗标.
相关概念视频
01:19Cadherins in Tissue Organization
3.1K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
3.1K
02:30Metastasis
5.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K
02:07Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
01:25Structure of Cadherins
3.6K
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
3.6K
01:35Cancer Cell Migration through Invadopodia
2.4K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.4K