菌体在治疗多抗药性ESKAPE病原体感染中的潜力
Izadora Dillis Faccin1, Gleyce Hellen de Almeida de Souza1, Jean Carlos Pael Vicente1
1Universidade Federal da Grande Dourados, Laboratory of Health Sciences Research (LPCS), Dourados, Mato Grosso do Sul, Brazil.
Expert opinion on therapeutic patents
|August 9, 2025
概括
菌体疗法是对抗ESKAPE病原体引起的抗菌素耐药性 (AMR) 的可行解决方案. 本综述分析了用于治疗感染和选择有效菌体的菌体应用的专利.
科学领域:
- 微生物学 微生物学
- 生物技术是生物技术.
- 传染性疾病 传染性疾病
背景情况:
- 抗菌素耐药性 (AMR) 是一个日益增长的全球健康威胁,减少了抗生素的有效性.
- 逃生病原体 (菌杆菌,金黄色葡萄球菌,肺炎菌,宝曼菌, Pseudomonas aeruginosa 和 Enterobacter spp.) 的存在. 是AMR的关键驱动因素.
- 菌体治疗为传统抗生素提供了有针对性的,特定的替代方案,有可能保护有益的微生物群.
研究的目的:
- 审查关于治疗ESKAPE病原体引起的感染的菌体申请的专利申请和已颁发的专利.
- 检查用于治疗用途的菌体选择方法.
- 为了突出人们对菌体基础的抗菌素耐药性策略日益增长的兴趣和投资.
主要方法:
- 在2024年10月18日之前对专利数据库进行全面搜索.
- 分析与ESKAPE病原体的细菌治疗相关的专利.
- 审查涉及菌体选择方法和菌体衍生产品的专利.
主要成果:
- 显著的专利活动表明,在抗菌素耐药性方面,菌体应用的研究热点.
- 专利涵盖了各种策略,包括菌体尾酒,计算设计,菌体衍生蛋白质和组合疗法.
- 越来越多的专利申请,特别是在中国和美国,凸显了全球研发重点.
结论:
- 菌体治疗是一种有前途的策略,以应对多药耐药ESKAPE病原体的挑战.
- 专利领域反映了在开发和应用菌体治疗传染病方面的重大创新.
- 基于菌体的方法是未来抗微生物开发的关键领域,特别是在资源有限的环境中.
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