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过敏原稳定性与表皮屏障功能在敏感患者中的关联

Hannes Nösslinger¹, Ewald Mair², Gertie Janneke Oostingh³

¹Department of Nutrition and Dietetics, Hospital of Merano (SABES-ASDAA), Teaching Hospital of Paracelsus Medical University, Merano-Meran, Italy.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

|August 9, 2025

概括

对稳定过敏原的敏感性与表皮屏障受损有关,特别是在患有湿疹的年轻患者中. 多重检测和早期免疫疗法可能有利于患有呼吸系统症状和共同敏感的儿童.

科学领域:

免疫学免疫学免疫学
过敏学过敏学
皮肤病学皮肤病学

背景情况:

过敏原的稳定性 (热量,pH) 影响过敏反应的严重程度和表现.
表皮屏障功能障碍是过敏原敏感化的关键因素.
不同的过敏原家族 (稳定与不稳定) 可能会引起不同的临床反应.

研究的目的:

研究患者特征和上皮屏障标记物之间的关联.
确定不同敏感性概况和临床结果之间的关系.
探索稳定与不稳定的过敏原敏感化在过敏性疾病中的作用.

主要方法:

在216名患者中,评估了特定免疫球蛋白E (sIgE) 对稳定的 (2S白蛋白,7/8S,11S球蛋白) 和不稳定的 (PR-10,蛋白质) 过敏原.
使用多重测定ALEX2进行过敏原特异性sIgE检测.
与人口统计,症状,研究人员全球评估 (IGA) 评分,超皮体水损失 (TEWL) 和部分呼出的氧化 (FeNO) 相关联的sIgE数据.

主要成果:

对稳定过敏原敏感的患者年轻,湿疹多,IGA得分高,TEWL升高.
结合胃肠道和皮肤症状在稳定的过敏原敏感化中更为普遍.
呼吸系统症状单独是不稳定的过敏原敏感性更常见,但更高的FeNO与稳定的过敏原的共同敏感性有关.

结论:

对稳定过敏原的敏感性与特定的上皮屏障功能障碍相关.
对于患有呼吸道症状的儿童,建议对稳定的食物过敏原进行多重检测.
对空气过敏原的早期特异性免疫疗法可以预防敏感个体的喘发展.

关键词:

亚历克斯2 亚历克斯2 过敏过敏过敏表面上皮质屏障的一个障碍.分子诊断分子诊断分子诊断多重测试多重测试方法

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