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心脏移植患者的结肠直肠癌:一个竞争性的风险分析

Alan Abboud¹, Amin Tajerian², Sharon Charles¹

¹Department of Medicine, Stony Brook University, Stony Brook, New York, USA.

European journal of clinical investigation

|August 9, 2025

概括

与普通人群相比,心脏移植接受者患结直肠癌 (CRC) 的风险明显更高. 心脏移植 (HT) 患者的CRC风险增加似乎不受年龄的影响.

科学领域:

心脏病学心脏病学
在瘤学瘤学.
移植手术移植手术

背景情况:

关于心脏移植 (HT) 患者结肠直肠癌 (CRC) 风险的数据有限.
在HT接受者,特别是45岁以下的接受者中缺乏CRC查建议.

研究的目的:

评估心脏移植 (HT) 后结直肠癌 (CRC) 的发生率.
调查心脏移植 (HT) 时的年龄对CRC风险的影响.

主要方法:

利用了TrinetX研究网络从4516名成年HT接受者的数据 (1996-2024).
使用ICD-10CM代码 (C18,C19,C20) 识别的CRC.
采用竞争性风险框架来估计由于死亡率较高的CRC发病率.

主要成果:

10年后的CRC累积发病率为1.73%,明显高于一般人口的发病率 (36.5/100,000人/年).
心脏移植 (HT) 时的年龄不是CRC风险的重要因素.
在男性和女性之间没有观察到CRC风险的显著差异.

结论:

与一般人群相比,心脏移植 (HT) 接受者患结直肠癌 (CRC) 的风险明显增加.
在HT接受者中,CRC风险与移植时的年龄无关.
建议考虑在所有心脏移植 (HT) 接受者中进行CRC查,无论年龄如何.

关键词:

结肠直肠癌是什么意思心脏移植心脏移植手术免疫抑制疗法是一种免疫抑制疗法.发生率的发生率.移植后的新生体

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