晚期发作的叶:桃体-海马体的扩大表明在脑电图和记忆障碍中发生了间歇性活动
Hirofumi Takeyama1, Riki Matsumoto2,3, Kiyohide Usami4
1Department of Neurology, Japanese Red Cross Otsu Hospital, Otsu, Japan.
概括
晚发性叶 (TLE) 中杏仁体和海马体的扩大与活动增加和记忆缺陷有关. 这一发现强调了杏仁体-海马体扩大作为TLE患者的显著临床指标.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 的研究研究.
背景情况:
- 晚发性叶 (TLE) 可能伴有杏仁体或海马体扩大.
- 这种扩大在老年TLE患者中的临床意义尚不清楚.
研究的目的:
- 调查桃体-海马体扩大在晚发性TLE的临床意义.
- 为了将结构性大脑变化与临床表现和EEG发现相关联.
主要方法:
- 对33名晚期TLE患者 (≥60岁) 和健康对照者的回顾性分析.
- 磁力共振成像体积与海马子子子场细分.
- 分析了的半学,间接性形放电 (IED),记忆测试,FDG-PET和神经自身抗体.
主要成果:
- 患者表现出左桃体和左海马-桃体过渡区域 (HATA) 的扩大,以及脑膜体积的减少.
- 葡萄糖低代谢被观察到在前和左海马尾部.
- 扩大的HATA或左桃体与更严重的记忆障碍相关.
- 海马体积比IED更大,体积增加与IED患病率更高有关.
结论:
- 杏仁体和海马体的扩大与晚发性TLE的间接性发性排泄 (IED) 有关.
- 桃体-海马体结构的扩大与这些患者的记忆障碍相关.
- 杏仁体和海马体的扩大是晚发性TLE中性兴奋和记忆缺陷的重要临床指标.
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