在怀孕期间系统性红斑狼的认知功能障碍
Philippe Leff1, Daniela Chinchilla-Ochoa2,3, Efraín Olivas-Peña2
1Reproductive and Perinatal Health Department, National Institute of Perinatology "Isidro Espinosa de los Reyes", Miguel Hidalgo, CDMX, México.
概括
认知功能障碍 (CD) 影响了近三分之一的孕妇患有静止系统性红斑狼 (SLE),通常与亚临床肝脏和脏问题有关. 这凸显了监测孕妇SLE患者认知健康的必要性.
科学领域:
- 风湿病学和免疫学
- 神经科学是一个神经科学.
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 系统性红斑狼 (SLE) 涉及异常免疫反应,可能影响肝脏,脏和中枢神经系统.
- 认知功能障碍 (CD) 是SLE患者常见的一种神经精神症状,影响日常生活和决策.
- 此前,在患有SLE的孕妇中,尤其是那些处于缓解期的孕妇中,CD的特征尚未被描述.
研究的目的:
- 确定怀孕妇女具有静止性SLE (QSLE) 的认知功能障碍 (CD) 的患病率.
- 在怀孕的QSLE患者中调查CD和血清自身抗体水平,补充成分和肝/标记物之间的关联.
- 探索CD与认知功能的特定领域之间的相关性.
主要方法:
- 进行了一项横截面研究,对63名患有QSLE的孕妇和52名健康的孕妇进行了第三季度的对照.
- 用蒙特利尔认知评估 (MoCA) 测试来评估认知功能障碍.
- 生物化学分析包括ELISA对自身抗体和补充成分,以及血清肌素和尿素测量.
主要成果:
- 与健康对照组相比,CD的患病率在怀孕的QSLE妇女中显著更高 (30.16%),比健康对照组 (5.7%).
- 在患有CD的QSLE孕妇中观察到肝脏标记物 (ALT) 和脏标记物 (尿素) 的血清水平升高.
- 在患有CD的QSLE组中,AST和ALT水平与MoCA得分有显著的相关性.
结论:
- 认知障碍,影响注意力,视觉空间/执行功能和抽象,在患有QSLE的孕妇中很普遍.
- 亚临床肝脏和功能障碍与这一群体的认知障碍有关.
- 这些发现强调了监测SLE孕妇的认知功能和亚临床器官损伤的重要性.
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