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Updated: Sep 12, 2025
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今年最重要的进展:膀癌
Andrea B Apolo1, Saad Atiq1, Andre R Kydd1
1Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Cancer
|August 9, 2025
概括
到2024年,膀癌治疗将以新的静脉内疗法,辅助和外科手术期间的免疫检查点抑制 (ICI),循环瘤DNA生物标志物以及转移性尿路细胞癌的新标准护理来推进.
科学领域:
- 在瘤学瘤学.
- 尿癌研究 尿癌研究
- 临床进展 临床进展
背景情况:
- 膀癌治疗在2024年取得了显著进展.
- 进步的关键领域包括静脉内疗法,免疫检查点抑制和生物标志物.
- 转移性尿路细胞癌治疗的景观已经发生了变化.
研究的目的:
- 审查2024年膀癌前五大临床进展.
- 突出新的治疗策略和生物标志物.
- 总结这些进展对患者治疗结果的影响.
主要方法:
- 对新的静脉注射药物输送系统 (如TAR-200) 的审查.
- 对肌肉侵入性膀癌 (MIBC) 中辅助和外科手术期间免疫检查点抑制 (ICI) 的第三期研究的分析.
- 评估循环瘤DNA (ctDNA) 作为MIBC的生物标志物.
- 对转移性尿路细胞癌的新一线治疗方法的评估.
主要成果:
- 新型静脉内疗法在非肌肉侵入性和肌肉侵入性膀癌 (MIBC) 中表现有前途.
- 辅助性ICI (nivolumab, pembrolizumab) 在高风险MIBC中使无病存活时间翻了一番.
- 经外科治疗的杜尔瓦卢马布在MIBC中改善了无事件和整体存活率.
- ctDNA是选择患者接受辅助ICI治疗的有前途的生物标志物.
- 恩福图马布维多丁加上潘布罗利祖马布使转移性尿路细胞癌的整体存活率翻了一番,成为新的护理标准.
结论:
- 膀癌治疗在2024年取得了显著的临床进展.
- 新的静脉注射药物,ICI策略和生物标志物正在改变医疗保健.
- 恩福图马布 (enfortumab) 与维多丁 (vedotin) 和潘布罗利祖马布 ( pembrolizumab) 的组合代表了对转移性疾病的重大突破.
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