主体基因组的融合,而不是肠道微生物群的融合,是哺乳动物地下适应的融合进化的基础
Kexin Li1, Yixin Liu1, Yehao Zhang1
1State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Cell reports
|August 9, 2025
概括
基因组分析显示,地下哺乳动物通过融合的遗传变化来适应地下生活,而不是肠道微生物组的进化. 这项研究提供了多学科的洞察力,以适应极端环境.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 微生物组研究的研究.
背景情况:
- 地下哺乳动物表现出独特的适应性,以在地下生存.
- 这些动物作为研究极端环境中的适应和融合的有价值的模型.
- 了解基因组和肠道微生物群适应对于进化见解至关重要.
研究的目的:
- 研究地下哺乳动物的基因组和肠道微生物群适应性.
- 确定在极端环境中适应和融合的基础分子机制.
- 探索宿主遗传与肠道微生物组在地下适应中的作用.
主要方法:
- 组装了中国竹鼠 (Rhizomys sinensis) 的染色体级基因组.
- 进行了转录组分析,以确定基因表达变化.
- 分析基因组数据以检测融合的遗传变化和基因家族扩展.
- 描述了肠道微生物组的结构和功能.
主要成果:
- 在中国竹鼠中发现了Hsp90基因家族的扩展,可能与缺氧适应有关.
- 在中国竹鼠中观察到与牙发育和视力相关的基因表达变化.
- 在地下哺乳动物中发现了视力,听力,免疫力和缺氧的融合遗传变化.
- 发现广泛的Krt9伪基化,可能与挖掘行为有关.
- 确定肠道微生物组的组成是由宿主类型和肠道形态形成的,而不是地下息地.
结论:
- 主体基因组的融合,而不是肠道微生物群的融合,推动了地下哺乳动物的适应.
- 多omics数据为地下适应的分子基础提供了新的见解.
- 这些发现突出了宿主基因和微生物组在适应极端环境时的独特进化路径.
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