德罗佩里多尔与哈洛佩里多尔治疗腹痛
Sebastian Gilt1, Brock R Townsend1, Andrea E Nisly2
1Department of Pharmacy, Wesley Medical Center, 550 N Hillside St, Wichita, KS 67214, United States of America.
与德罗佩里多尔相比,哈洛佩里多尔在急诊室的未分化腹痛中显著减少了阿片类药物的使用. 需要进一步的研究来证实利的存在.
科学领域:
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 哈洛佩里多尔和德罗佩里多尔是具有急诊室应用的抗精神病药物.
- 这两种药物都可能减少对未分化腹痛 (UAP) 的阿片类药物需求.
- 在UAP管理中,对于haloperidol与droperidol存在有限的比较数据.
研究的目的:
- 为了比较halooperidol和droperidol在减少阿片类药物 (吗啡毫等效 - MME) 的疗效,对UAP的要求.
- 评估二次结果,包括救援药物,住院和不良事件.
主要方法:
- 对患有UAP的成年患者进行了回顾性单中心研究.
- 排除标准包括需要紧急手术或急躁症治疗.
- 主要结局:给予MME的差异;次要结局:救援药物,入院,停留时间,不良影响.
主要成果:
- 分析了100名患者 (50名haloperidol,50名droperidol) 的情况.
- 哈洛佩里多尔组的中位数MME (0) 显著低于德罗佩里多尔组的中位数 (10) (p=0.033).
- 在二次结果 (包括安全事件) 中没有发现显著差异.
结论:
- 与德罗皮多尔相比,哈洛皮多尔在UAP中显著减少了MME.
- 需要高质量的研究来验证利在UAP多模式疼痛管理中的作用.
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