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抗抑郁药物药理疗在儿童PTSD有或没有并发性ADHD:一个全国性的回顾性研究

Diab A Ali¹, Elijah Hale², Andy Ascencio²

¹Department of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA; Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Journal of psychiatric research

|August 9, 2025

概括

患有创伤后应激障碍 (PTSD) 和注意力缺陷多动障碍 (ADHD) 的年轻人比单独患有PTSD的人更容易被处方抗抑郁药物和更换药物. 对这种复杂的并发症还需要进一步的研究.

科学领域:

儿童和青少年精神病学儿童和青少年精神病学
神经发育障碍神经发育障碍
心理健康研究心理健康研究

背景情况:

创伤后应激障碍 (PTSD) 和注意力缺陷多动障碍 (ADHD) 经常在年轻人中同时发生.
虽然心理治疗是PTSD和ADHD的兴奋剂的标准,但抗抑郁药通常用于并发性内化症状.
对于患有并发性PTSD和ADHD的年轻人使用抗抑郁药物的数据有限,特别是关于外部化行为.

研究的目的:

调查和比较抗抑郁药物处方模式和治疗进展,在年轻人与PTSD单独与那些伴并发性PTSD和ADHD.
在这些儿科群体中分析选择性色素再吸收抑制剂 (SSRI) 和色素-上腺素再吸收抑制剂 (SNRIs) 的使用.

主要方法:

一项使用美国TrinetX数据库的回顾性队列研究.
分析了83,252个21岁以下患有PTSD的个人记录,其中包括37,003名伴随性ADHD (PTSD-ADHD) 和46,249名仅患有PTSD.
两个队列之间的SSRI和SNRI处方流行率和治疗延续率的比较.

主要成果:

患有PTSD-ADHD的年轻人显示,与仅患有PTSD的年轻人相比,SSRI处方的可能性更高.
匹配分析显示,在PTSD-ADHD队列中,SSRI和SNRI使用量增加.
在这两组中,很大一部分人没有在PTSD诊断后开始服用抗抑郁药,而PTSD-ADHD组的开始率较低.

结论:

与那些单独患有PTSD的年轻人相比,患有并发性PTSD和ADHD的年轻人表现出明显的抗抑郁药物处方模式.
这些发现突出显示,在患有PTSD-ADHD的年轻人中,抗抑郁药的启动和切换的可能性更大.
需要进一步研究青年伴随性PTSD和ADHD的治疗策略和机制.

关键词:

更多关于 ADHD ADHD 的文章抗抑郁药是一种抗抑郁药.孩子孩子孩子孩子孩子孩子伴发病性疾病伴发病性疾病创伤后应激障碍 (PTSD) 是一种治疗方法治疗方法

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