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重金属,表观遗传衰老和死亡率:一个队列研究

Hua Wang¹, Yunyun Liu², Shuxiang Yan³

¹Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, Hunan Engineering Research Center of AI Medical Equipment, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.

Ecotoxicology and environmental safety

|August 9, 2025

概括

环境金属暴露,包括和,与较高的死亡风险有关. 表观遗传衰老标志物部分调解了这种关联,突出了衰老和环境健康的关键机制.

科学领域:

环境健康环境健康
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
毒理学毒理学毒理学

背景情况:

衰老受遗传学和环境的影响,但表观遗传衰老对环境暴露和死亡率的作用尚不清楚.
了解这些联系对于公共卫生和衰老研究至关重要.

研究的目的:

研究尿路金属暴露,表观遗传年龄加速标记 (EAMs) 和死亡风险之间的关联.
评估EMS在金属暴露与死亡率关系中的调解作用.

主要方法:

分析了807名国家健康和营养检查调查参与者的数据.
从DNA甲基化残留物中提取了6个EAM.
使用多重回归和调解分析来评估金属暴露,EMS和死亡率之间的关系.

主要成果:

尿液中的高,,和与增加的死亡风险相关.
金属暴露加速了表观遗传衰老,特定的金属与EAM如GrimAge-Resid和DunedinPoAm强烈相关.
EAMs部分调解了/暴露与死亡风险之间的关系.

结论:

尿道金属暴露与死亡风险增加有关.
表观遗传衰老部分介导金属暴露和死亡率之间的联系.
这些发现强调了表观遗传衰老在环境健康结果中的作用.

关键词:

生物衰老生物衰老表观遗传年龄表观遗传年龄表观遗传年龄加速加速暴露于金属中的金属.死亡率死亡率死亡率

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