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保护水源免受动物和便污染,以防止ARG污染

Chengcheng Deng¹, Yaming Zhang², Yixin Ma¹

¹School of Public Health, Lanzhou University, Lanzhou, Gansu, China.

Ecotoxicology and environmental safety

|August 9, 2025

概括

抗生素耐药性基因 (ARG) 通过被动物和便污染的水传播. 细菌群落,而不是移动的遗传元素,主要驱动ARG的分布,强调需要保护水源.

科学领域:

环境科学环境科学
微生物学微生物学
遗传学遗传学是一种遗传学.

背景情况:

抗生素耐药性基因 (ARG) 对公众健康和环境安全构成重大威胁.
了解ARG在生态系统中的来源和传播途径对于有效的控制策略至关重要.

研究的目的:

确定各种环境媒介 (水,土壤,动物,寄生虫载体) 中的ARG的主要来源.
阐明细菌社区结构与移动遗传元素 (MGE) 在ARG分布中的作用.
为预防ARG污染提供基于证据的建议.

主要方法:

16S rRNA基因测序和高通量定量PCR用于表征微生物群落和ARG.
快速预期最大化微生物源追踪 (FEAST) 分析以确定ARG来源.
在选定的清洁生态系统内分析水,土壤,动物和它们相关的寄生虫载体中的ARG.

主要成果:

细菌社区结构显著影响ARG分布 (47.1%),远远超过了MGE的影响.
水是ARG的主要通道,接收54.78%的土壤ARG和19.40%的动物ARG.
动物微生物群 (肠道和表面) 是水中发现的ARG的主要来源 (80%),土壤贡献了17.81%.

结论:

水体作为ARG的关键传播者,动物废物是主要的污染源.
细菌社区组成是ARG模式的主要驱动因素,强调微生物生态在耐药性传播中的重要性.
防止ARG污染需要采取严格的措施,保护水源免受来自动物的污染,特别是便.

关键词:

在 ARG 中,有 ARG 的存在.抗生素耐药性基因是抗生素耐药性的基因.预防污染预防污染环保ARG正在扩散.水的污染污染水的污染

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