年龄和过敏原类型对慢性鼻炎儿童敏感性变化的影响
Sucheera Nokkaew1, Wanlapa Jotikasthira1, Potjanee Kiewngam1
1Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University Bangkok, Thailand.
International journal of pediatric otorhinolaryngology
|August 9, 2025
概括
患有鼻炎的儿童的过敏原敏感性随着时间的推移而发生变化,观察到皮肤刺伤测试 (SPT) 的阳性率增加. 对于治疗慢性鼻炎,可能需要重复SPT.
科学领域:
- 儿科过敏和免疫学
- 免疫学 免疫学 免疫学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 对于儿童慢性鼻炎的诊断和管理,对空气过敏原敏感性评估至关重要.
- 了解敏感化模式的时间变化对于有效的临床管理至关重要.
研究的目的:
- 在一组被诊断患有慢性鼻炎的儿童中,研究空气过敏原敏感性的纵向变化.
- 确定影响这些敏感化转移的特定过敏原和患者因素.
主要方法:
- 一项回顾性队列研究,涉及300名患有慢性鼻炎的儿童,他们在2009-2019年期间接受了初始气敏素皮肤刺伤测试 (SPT).
- 在2022-2024年期间,通过SPT进行了重新评估,以评估敏感性状态的变化.
- 分析的重点是比较初始和后续的SPT结果,包括新敏感率和负转换率.
主要成果:
- 在研究期间,SPT阳性率从71.3%显著增加到83.7% (p < 0.001).
- 室内灰尘 (HDM) 和是最常见的敏感剂. 敏感性模式在56.7%的儿童中发生了转变,HDM和猫敏感性显著增加.
- 负转换率因过敏原而异,百慕大草的负转换器与持久的阳性反应器相比,最初的小麦片大小较小.
结论:
- 患有鼻炎的儿童的过敏原敏感化模式是动态的,随着时间的推移而演变.
- 过敏原类型和患者年龄是影响这些变化的重要因素.
- 对于患有持续或不受控制的鼻炎症状的儿童,可能需要定期通过SPT重新评估.
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