解锁肠肺轴:Feixin作为低氧肺高血压中新型调节剂
Fei-Ying Wang1, Jian Yi2, Ling-Ling Zhou1
1Department of Respiratory Diseases, Medical School, Hunan University of Chinese Medicine, Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, Changsha 410208, China.
概括
费辛 (FXD) 通过调节肠道微生物群和代谢物,有效治疗缺氧性肺高血压 (HPH). 这种传统中医药恢复了肠道屏障功能,并为HPH提供了一种新的治疗策略.
科学领域:
- 传统中国医药 传统中国医药
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
- 心血管研究研究心血管研究
背景情况:
- 费辛 (FXD) 是一种用于慢性肺性心脏病和缺氧性肺高血压 (HPH) 的中国传统医药.
- 通过FXD预防HPH的精确药理机制尚未完全理解.
- 研究FXD在HPH中的作用需要了解其与肠道微生物群的相互作用.
研究的目的:
- 评估FXD对HPH的预防和治疗疗效.
- 为了确认HPH,肠道微生物群和FXD治疗之间的关联.
- 阐明FXD在HPH中的作用的基本机制.
主要方法:
- 使用多个体内模型:HPH大鼠,微生物群枯竭和便微生物群移植 (FMT).
- 通过血液动力学测量,心脏功能,组织病理学和蛋白质表达来评估HPH表型.
- 分析了肠道微生物群组成 (16S rRNA测序),代谢物 (非向和向代谢物) 和肠道屏障完整性 (电子显微镜,免疫光).
主要成果:
- 在老鼠中,FXD显著改善了HPH,改善了肺血管重塑,右心室缩和全身炎症.
- FXD恢复了肠道屏障功能和调节了肠道微生物群,增加了有益细菌 (乳酸菌) 和减少了病原体.
- FXD使关键代谢物正常化,包括增加eicosapentaenoic acid (EPA) 和docosahexaenoic acid (DHA),并减少5-hydroxytryptamine (5-HT),可能通过TLR4/MyD88/NF-κB通路.
结论:
- 通过调节肠道微生物群和相关代谢物,FXD减轻了HPH.
- 在HPH治疗中,FXD显示出作为肠道微生物群调节器的潜力.
- 这项研究提供了一种新的治疗策略,通过微生物群调节来提高HPH治疗疗效.
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