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Lisa Scheidegger¹, Heike Frauchiger-Heuer², Esther Birindelli²

¹Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; Department of Anesthesiology and Perioperative Medicine, University Hospital Zurich, Zurich, Switzerland.

Human pathology

|August 9, 2025

概括

管道癌 in situ (DCIS) 的微侵袭并没有显著改变整体复发率. 然而,具有特定高风险特征的微侵袭性DCIS需要进一步研究以制定量身定制的治疗策略.

科学领域:

在瘤学瘤学.
病理学病理学病理学
乳腺癌研究研究乳腺癌研究

背景情况:

在位管道癌 (DCIS) 是一种非侵入性乳腺癌,通常通过化检测出来.
虽然通常用手术治疗,但DCIS患者的一个子集经历了复发.
微侵袭 (≤1毫米侵袭焦点) 提出了诊断和治疗方面的挑战,其生物行为受到争论.

研究的目的:

为了确定DCIS与微侵入性焦点是否代表与纯 DCIS 相比,一个独特的生物实体.
分析微侵袭对复发率和生存率的影响.
为了确定与微侵袭DCIS的结果相关的病理和临床因素.

主要方法:

对148名经过手术治疗的DCIS患者进行了回顾性分析,并提供完整的数据.
分类为纯粹的DCIS (126名患者) 和带有微侵袭的DCIS (22名患者).
微侵袭和病理参数与使用卡普兰-梅尔曲线的时间到事件 (TTE) 的相关性.

主要成果:

总体而言,18.9%的患者经历了事件 (复发性DCIS,侵入性癌症或乳腺癌死亡).
带有微侵袭和没有微侵袭的DCIS在TTE中没有显著差异.
微创性DCIS与广泛的疾病,高核级,亡,狭窄的边缘,年轻的年龄和缺乏辅助疗法的更高的复发率有关.

结论:

具有微侵入性焦点的DCIS的生物行为在总体时间到事件方面与纯粹的DCIS没有显著差异.
然而,微侵袭性DCIS中的特定高风险特征与复发率的增加相关.
需要进一步的研究来了解微创性DCIS的生物学,并探索不同的治疗方案.

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