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Updated: Sep 12, 2025

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通过超声波激活的纳米滴来准瘤层:破坏外体驱动的微环境交叉连接,以提高抗瘤功效

Yuanyuan Yang¹, Rui Liu¹, Hongtao Lv²

¹Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.

Journal of controlled release : official journal of the Controlled Release Society

|August 9, 2025

概括

这项研究开发了针对瘤微环境细胞的新型纳米滴 (M/H-I-NDs),抑制外体释放,并在临床前模型中显示出显著的抗瘤和抗转移效应.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

瘤微环境 (TME) 对瘤进展至关重要.
在TME中,与瘤相关的巨细胞 (TAM) 和与癌症相关的纤维细胞 (CAF) 分泌出促进瘤生长和转移的外体.
准TME层细胞及其外体分泌是一种有前途的抗瘤策略.

研究的目的:

为了构建和评估Man/HTTIPKV-imipramine-nanodroplets (M/H-I-NDs) 以针对TAM和CAF的目标.
研究M/H-I-NDs与超声波向微泡破坏 (UTMD) 对乳腺癌的联合治疗效果.
评估这种联合治疗的体外和体外抗瘤和抗转移疗效.

主要方法:

使用超声波乳化合成M/H-I-ND,并加载了新型外体酶体抑制剂imipramine.
使用Man和HTTIPKV连接体进行表面修改,提高了准效率.
在体外和体内研究中使用了4T1乳腺癌细胞和小鼠模型,并与UTMD结合用于药物输送.

主要成果:

M/H-I-NDs显示高瘤组织积累 (3.4倍增加) 和高效的药物透.
M/H-I-NDs/UTMD组合显著抑制了来自TAM (87.5%) 和CAF (54%) 的外体生成.
这种疗法在体外显著降低瘤细胞活动 (~80%) 和体内瘤体积减少 (~85%).

结论:

与UTMD结合的M/H-I-NDs代表了针对乳腺癌的有效的侧膜向治疗.
这一策略同时通过双联体向和超声波增强来破坏TAM和CAF外体信号传输.
这种方法显示出在抗瘤治疗中临床翻译的巨大潜力.

关键词:

外基因组是外基因组的组成部分.这些纳米滴是纳米滴.与瘤相关的巨细胞.超声波准的微气泡破坏与癌症相关的纤维细胞.

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