中年和老年人的认知变化基于小组的轨迹建模:系统性审查
Huan Zhang1, Hongli Chen1, Xiaotong Ding2
1School of Nursing, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100144, China.
Ageing research reviews
|August 9, 2025
概括
许多老年人通过生活方式选择和社会联系保持稳定的认知健康. 然而,快速的认知衰退与严重的健康问题有关,这凸显了对保护因素的进一步研究的需要.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 认知健康对于成功的衰老至关重要.
- 了解认知轨迹及其决定因素至关重要.
研究的目的:
- 系统地审查使用基于集团的轨迹建模用于认知轨迹的研究.
- 确定影响认知轨迹的因素.
- 研究认知轨迹与健康结果之间的关系.
主要方法:
- 在五个数据库中进行系统的文献搜索.
- 包括的研究确定了两个或两个以上不同的认知轨迹.
- 坚持PRISMA声明进行系统审查.
主要成果:
- 分析了35项研究 (2007-2024年) 与318-19422名参与者进行了分析.
- "高度稳定"和"中度衰退"是最常见的认知轨迹.
- 稳定认知的保护因素包括教育,积极的生活方式,良好的睡眠和社交网络. 心血管疾病,糖尿病和抑郁症与衰老有关. 像APOE ε4这样的生物标志物,粉样荷载和tau与下降有关. 快速下降与痴呆症,死亡率和残疾增加有关.
结论:
- 很大一部分老年人表现出稳定的认知功能,受到生活方式因素和疾病管理的支持.
- 认知衰退的不良结果强调了对可修改因素的研究的需要.
- 对生物标志物的进一步研究对于理解认知衰老和痴呆症预防至关重要.
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