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瘤相关巨细胞中的脂质代谢重编程:功能极化和瘤免疫调节的关键驱动因素

Xianglong Feng¹, Jiahao Zhang², Boyi Yu¹

¹University of Chinese Academy of Sciences, Beijing 101408, China; Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China.

Critical reviews in oncology/hematology

|August 9, 2025

概括

瘤相关巨细胞 (TAMs) 通过脂质代谢来调节瘤的进展. 向TAM脂质代谢提供了一种新的策略,可以增强抗瘤免疫力和癌症免疫疗法.

科学领域:

免疫学免疫学免疫学
癌症生物学癌症生物学
代谢调节代谢调节代谢调节

背景情况:

瘤相关巨细胞 (TAMs) 是瘤微环境 (TME) 中的关键免疫细胞.
TAMs动态调节瘤的进展,特别是通过代谢重编程.
脂质代谢是受TAMs影响的关键途径,影响其表型和功能.

研究的目的:

研究TAM脂质代谢在调节瘤微环境中的作用.
探索针对TAM脂质代谢作为癌症治疗的策略.
评估针对TAM脂质代谢与现有免疫疗法的协同作用潜力.

主要方法:

分析TAM表型 (M1与M2) 和它们的可塑性.
调查主要的脂质代谢途径,包括脂肪酸氧化 (FAO),胆固醇稳态和脂代谢.
在临床前模型中评估针对TAM脂质代谢的治疗策略.

主要成果:

TAMs表现出显著的可塑性,在支持瘤 (M2) 和抗瘤 (M1) 现型之间切换.
脂质代谢途径,包括粮农组织和胆固醇平衡,是TAM表型调节的核心.
准TAM脂质代谢可以将TME重塑到一种抗瘤状态.

结论:

在TME中,TAM脂质代谢是它们的功能和可塑性的关键决定因素.
调节TAM脂质代谢是癌症治疗中一个有前途的治疗策略.
将针对TAM的脂质代谢干预与免疫检查点抑制剂等免疫疗法相结合,可能会提高治疗效率,并代表精确瘤学的新方向.

关键词:

胆固醇的新陈代谢粮农组织粮农组织粮农组织粮农组织.脂质代谢的代谢方式这就是TAMs.

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