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乳腺癌中的微生物组动态:机制,治疗影响和研究差距

Magdalene Eno Effiong¹, Nwamaka Cynthia Ikeji², Mercy Bella-Omunagbe³

¹Department of Biochemistry, College of Science and Technology, Covenant University, Ota, Canaanland, Ogun State PMB 1023, Nigeria; Covenant Applied Informatics and Communication Africa Centre of Excellence (CApIC-ACE), Nigeria; Covenant University Public Health and Wellbeing Research Cluster (CUPHWERC), Covenant University, Ota, Canaanland, Ogun State PMB 1023, Nigeria.

Critical reviews in oncology/hematology

|August 9, 2025

概括

微生物群通过影响雌激素代谢,DNA损伤和免疫反应来影响乳腺癌风险和治疗. 了解这些肠道和乳腺微生物群相互作用对于开发个性化癌症疗法至关重要.

科学领域:

在瘤学瘤学.
微生物学微生物学
遗传学是一个遗传学.

背景情况:

乳腺癌是全球女性死亡的主要原因之一.
微生物群,特别是肠道和乳腺,越来越多地被认为在癌症的发展和治疗中的作用.
现有研究强调了探索乳腺癌发生过程中的微生物驱动机制的必要性.

研究的目的:

系统地审查和综合当前关于微生物组在乳腺癌中的作用的文献.
确定微生物群影响乳腺癌风险,进展和治疗结果的关键机制.
确定研究缺口,特别是关于地理差异的缺口.

主要方法:

102篇同行评审文章的系统叙事审查.
在PubMed,Scopus和Web of Science数据库中进行的搜索.
纳入标准集中在将微生物组与乳腺癌联系起来的研究上.

主要成果:

微生物通过雌激素代谢,DNA损伤和免疫调节影响乳腺癌风险.
化疗改变了微生物的组成,影响了治疗的疗效和副作用.
特定的细菌可以预测治疗反应,而失生症与炎症和认知衰退有关.
存在显著的研究缺口,特别是在撒哈拉以南非洲,包括尼日利亚.

结论:

微生物组在乳腺癌中发挥着多方面的作用,影响荷尔蒙调节,免疫力和治疗反应.
个性化瘤学和精准医学可以利用微生物群的洞察力.
未来的研究应该集中在不同的队列和机制研究上,以解决差异,并开发有针对性的干预措施.

关键词:

乳腺癌乳腺癌乳腺癌乳腺微生物组是如何形成的癌症风险因素癌症风险因素致癌的发生是致癌的产生.地理上的差异.我们的肠道微生物组.纵向研究是指长度研究.个性化治疗是个性化的治疗.治疗结果的治疗结果.

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