生物学参考区间的基于种族的变化 - 一个系统的范围审查审查
Sasidharan Sivakumar1, Ishika Makhija2, Ruchika Bhagat2
1Discovery Research Division, Indian Council of Medical Research, ICMR Headquarters, Ansari Nagar, New Delhi 110029, India.
概括
来自西方种群的生物参考区间 (RIs) 不适用于全世界. 本次审查强调了生物标志物水平的显著基于种族的变化,强调了需要特定人群的RI,以确保准确的诊断和公平的医疗保健.
科学领域:
- 临床诊断 临床诊断 临床诊断
- 生物标志物的分析分析.
- 人口健康 人口健康
背景情况:
- 传统的生物参考间隔 (RIs) 往往是基于同质的西方种群.
- 一般化RI可能不准确地反映各种遗传,环境和生活方式因素.
- 这可能导致诊断不准确和健康不平等在代表性不足的种族群体.
研究的目的:
- 对生物参考区间 (RIs) 中基于种族的变化进行范围审查.
- 突出人群特异性RI对于改善临床决策的重要性.
- 在不同族裔群体中发现有关RI的研究缺口.
主要方法:
- 范围审查遵循乔安娜·布里格斯研究所 (JBI) 的指导方针.
- 在主要数据库 (MEDLINE,Embase,Scopus,Web of Science) 进行文献搜索,截至2024年12月.
- 使用人口概念背景 (PCC) 框架对种族特异差异的观察性研究进行资格评估.
主要成果:
- 十五项研究符合纳入标准,分析了多民族人口.
- 在各族群中观察到生物标志物水平 (例如脂质谱,维生素B12,抗穆勒激素) 的显著差异.
- 对于代表性不足的民族群体,研究发现了研究缺口,这表明一般化RI的不足.
结论:
- 对于特定种族的RI来提高诊断准确性是非常需要的.
- 开发具有包容性和代表性的RI对于促进公平的医疗保健结果至关重要.
- 需要进行进一步的研究,以建立针对特定人口的RI的强有力的方法.
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