高脂肪和低纤维饮食提高肠道抵抗体:一个比较的元基因组研究
Yingbo Shen1, Da Sun1, Kun Chen2,3
1State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
NPJ biofilms and microbiomes
|August 9, 2025
概括
高脂肪/低纤维饮食会增加肠道抗菌素耐药性 (AMR),而高纤维/低脂肪饮食会降低耐药性. 采用高纤维饮食可能会减少人类肠道中的AMR负担.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 抗菌素耐药性 (AMR) 是一个关键的全球健康威胁.
- 肠道微生物组含有AMR决定因素,并受到饮食的影响.
- 饮食模式对肠道抗体的确切影响尚未完全理解.
研究的目的:
- 为了研究高脂肪/低纤维和高纤维/低脂肪饮食对肠道微生物组抗性的影响.
- 在不同的饮食条件下识别关键的细菌种群和与AMR发展相关的移动遗传元素.
- 在小鼠模型和人群中比较饮食对AMR的影响.
主要方法:
- 在高脂肪/低纤维和高纤维/低脂肪饮食的小鼠中进行饮食干预研究.
- 对抗体,毒性基因 (VGs) 和移动遗传元素 (MGE) 丰富性的分析.
- 网络分析以确定抗菌素耐药性基因 (ARG) 和VG的细菌宿主.
- 对人类群体的饮食模式和抗体水平进行比较分析.
主要成果:
- 高脂肪/低纤维饮食显著增加了小鼠的抗体,VG和MGE丰度.
- 高纤维/低脂肪饮食导致抵抗性,VG和MGE丰度的显著下降.
- 细菌类,细菌类和菌类被确定为ARG和VG的关键宿主.
- 人类数据显示,高脂肪饮食与更高的抗体水平以及高纤维饮食与更低的抗体水平之间存在相关性.
结论:
- 饮食模式对肠道微生物群的抗菌素耐药性有深远的影响.
- 高纤维/低脂肪饮食可以减轻肠道微生物群中AMR的发展.
- 公共卫生建议应考虑促进高纤维饮食,以应对抗药物耐药性负担.
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