在使用GLP-1抗原剂治疗期间,在内镜手术期间吸收风险
Maryana Stryelkina1, Robert Molina1, Thomas Janice1
1Division of Internal Medicine, Department of Medicine, Baylor Scott & White Medical Center, Temple, TX, 76508, USA.
Digestive diseases and sciences
|August 9, 2025
概括
类似葡萄糖-1受体激动剂 (GLP-1RA) 的使用在EGD或结肠镜等内镜手术期间不会增加吸收风险. 吸引事件在EGD中更常见,但GLP-1RA疗法与风险增加无关.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 患者安全 患者安全
背景情况:
- 类似葡萄糖-1受体激动剂 (GLP-1RAs) 广泛用于2型糖尿病和体重管理.
- 由于GLP-1RAs对胃排空的影响,人们对内镜期间吸入风险存在担忧.
- 关于接受结肠镜检查的GLP-1RA使用者,关于吸血风险的数据有限.
研究的目的:
- 为了评估和比较接受食道胃管腺镜术 (EGD) 和结肠镜术的患者的吸血风险.
- 为了确定GLP-1RA治疗是否与这些程序中的吸收风险增加有关.
主要方法:
- 从2017年7月到2024年7月,对13523名成年患者 (18-70岁) 的回顾性队列研究.
- 通过GLP-1RA使用分层的患者;主要结局是30天内与吸收相关的诊断 (ICD-10代码).
- 奇平方测试和后勤回归用于评估手术类型,GLP-1RA使用和吸收风险之间的关联.
主要成果:
- 在EGD检查后,吸血事件比结肠镜检查更频繁 (aOR=2.36,P=0.0200).
- 在使用GLP-1RAs的患者中没有观察到吸收事件.
- 黑人种族与增加的愿望风险相关 (aOR=2.77,P=0.0061);较高的BMI与较低的风险相关.
结论:
- 与结肠镜相比,EGD的吸收风险更高,独立于GLP-1RA的使用.
- 在这个队列中,GLP-1RA疗法与吸血风险增加无关.
- 常规GLP-1RA使用可能不会在门诊内镜设置中增加吸收风险;有必要进行前性研究.
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