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使用in-situ cryo-TEM进行异质冰核和结晶路径的分子解析映射

Zibing Wang^1,2, Zifeng Yuan³, Mouyang Cheng³

¹Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China.

Nature communications

|August 9, 2025

概括

冰在寒冷表面的形成是通过无障碍,吸附介导的途径发生的. 这项研究揭示了异质冰核形成和生长所涉及的分子步骤,为结晶过程提供了新的见解.

科学领域:

材料科学材料科学材料科学
物理化学物理化学
地质物理学地质物理学

背景情况:

结晶在许多科学学科中至关重要.
冰的形成机制,特别是异质核形成,仍然不太清楚.
了解冰核形成对从气候科学到材料工程等领域至关重要.

研究的目的:

阐明在低温,低压条件下形成冰的分子机制.
开发一个分子分辨率测绘和热力学框架,用于沉积结.
调查非经典的核化路径和界面能量学的作用.

主要方法:

在现场结合低温传输电子显微镜 (cryo-TEM).
使用分子动力学 (MD) 模拟.
将实验观察与理论建模相结合,进行全面的分析.

主要成果:

证明了异质冰核形成的吸附介导,无障碍的途径.
确定了一系列的步骤:无形冰吸附,冰I核化/增长,奥斯瓦尔德成熟,沃尔夫构造和凝聚.
展示了界面自由能量最小值在冰形成中的支配作用.

结论:

提供了对异质冰核化机制的直接分子层面的见解.
扩大了对非经典核化途径的理解.
突出了界面能量学对冰晶形态和质量的关键影响.

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相关概念视频

Cryo-electron Microscopy

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...