尿酸酸与前列腺特异抗原之间没有前列腺疾病的关联:一个队列研究
Zhiyi Chen1, Enpu Zhang1, Lu Gan1
1Department of Urology, The Third Affiliated Hospital of Shenzhen University, Shenzhen Luohu Hospital Group Luohu People's Hospital, Shenzhen, 518000, China.
BMC urology
|August 9, 2025
概括
尿中的酸盐水平与患有灰色区域TPSA的个体的前列腺特异性抗原比率有负相关性. 这一发现可能有助于减少前列腺癌的过度治疗.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 环境健康 环境健康
- 在瘤学瘤学.
背景情况:
- 将酸盐减少为酸盐具有致癌性,并与各种疾病有关.
- 关于酸盐对泌尿系统的影响及其与前列腺特异性抗原 (PSA) 的关联,目前的研究有限.
研究的目的:
- 为了研究尿酸中酸盐水平和PSA之间的关系.
- 为了澄清尿中酸盐和PSA在灰色区域TPSA的个体之间的关联.
主要方法:
- 使用了加权通用线性模型,单变量分析,森林地块和多变量分析.
- 一般化添加剂模型 (GAM) 用于可视化PSA和尿酸之间的关系.
- 为了确保协会的稳定性,进行了子组分析.
主要成果:
- 尿中的酸盐与总PSA (TPSA),自由PSA (FPSA) 和PSA比率呈负相关性.
- 只有PSA比率在调整混因子后 (β = -632.7; P = 0.011) 保持了显著的负相关性.
- 观察到一种非线性关系,尿中酸盐最初稳定,然后下降.
结论:
- 在患有灰色区域TPSA的个体中,尿酸和PSA比率之间存在负相关性.
- 这些发现有助于更好地了解尿酸对PSA的影响.
- 这些结果可能有助于减少这一群体的前列腺癌过度治疗.
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