基于多株L. crispatus的阴道共生菌对阴道微生物组的影响:随机的安慰剂对照试验
Jacques Ravel1, Sheri Simmons2, Eleni Greenwood Jaswa3
1Center for Advanced Microbiome Research and Innovation, Institute for Genome Sciences and Department of Microbiology & Immunology, University of Maryland, School of Medicine, Baltimore, MD, USA.
NPJ biofilms and microbiomes
|August 9, 2025
概括
一种阴道共生菌有效地恢复了由L. crispatus (CST I) 主导的健康的阴道微生物组. 这种多菌株益生菌显著增加了有益细菌,并减少了有害微生物,如Gardnerella vaginalis和Candida.
科学领域:
- 微生物学 微生物学
- 妇科 妇科医生 妇科
- 临床试验 临床试验
背景情况:
- 阴道微生物群在生殖健康中起着至关重要的作用.
- 乳酸菌 (L. crispatus) 是维持健康的阴道环境的关键物种,通常与社区国家类型I (CST I) 相联系.
- 阴道微生物不平衡的特征是失生症,与各种妇科问题有关.
研究的目的:
- 评估多菌株阴道共生菌在恢复健康的阴道微生物组中的有效性.
- 评估协生菌对L. crispatus丰富性的影响以及转向CST I. 的转变.
- 为了研究共生菌对减少潜在的致病微生物的作用,如Gardnerella vaginalis和Candida.
主要方法:
- 进行了一项临床试验 (NCT05659745) 以比较多菌株阴道共生药与安慰剂.
- 分析了阴道微生物组的组成,以确定L. crispatus的丰富性和CST I的流行率.
- 该研究测量了L. crispatus水平的变化以及协生和安慰剂组中转化为CST I的速度.
- 量化了Gardnerella vaginalis和Candida的存在,以评估它们的减少.
主要成果:
- 与安慰剂相比,阴道共生菌显著增加了L.crispatus (p <0.05).
- 与安慰剂组 (11%;p < 0.002) 相比,协生组的参与者中,显著更高的比例实现了转换到CST I (90%).
- 协生治疗导致了Gardnerella vaginalis和Candida水平的降低.
结论:
- 一种多菌株的阴道共生菌有效地促进由L. crispatus (CST I) 主导的阴道微生物组.
- 这种共生菌在恢复有益细菌和减少关键机会性病原体方面表现出显著的有效性.
- 这些发现支持了阴道共生菌作为治疗阴道失生症的治疗策略的潜力.
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