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甲状腺功能和甲状腺平衡参数之间的关联以及慢性病的流行率和全因和心血管死亡率:基于人口的研究
Xue Liu1, Yuhao Zhang2, Yuchen Li1
1Department of Endocrinology, Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
BMC public health
|August 10, 2025
概括
甲状腺功能和恒温参数与慢性病 (CKD) 患病率和死亡率有关. 像FT3/FT4和TFQIFT3这样的特定甲状腺指标显示,在CKD患者中死亡率降低的相关性.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 流行病学 流行病学
背景情况:
- 慢性病 (CKD) 影响了相当一部分成年人群.
- 甲状腺功能障碍越来越多地被认为是CKD患者的并发症.
- 了解甲状腺功能和CKD结果之间的相互作用对于患者管理至关重要.
研究的目的:
- 调查甲状腺功能和甲状腺平衡参数与CKD患病率之间的关联.
- 探索甲状腺功能和平衡对CKD患者全因和心血管死亡率的影响.
- 用先进的统计方法分析非线性关系.
主要方法:
- 利用了2007-2012年国家健康和营养检查调查 (NHANES) 的数据,包括8,526名成年人 (1,625名患有CKD).
- 评估了甲状腺功能 (FT3,FT4,TSH) 和恒温参数 (FT3/FT4,TFQI,TT4RI,TT3RI,TSHI).
- 使用加权后勤回归,Cox比例危险模型和Kaplan-Meier分析来检查关联和生存结果.
主要成果:
- 自由甲状腺素 (FT4) 与CKD患病率正相关.
- 自由三甲状腺素 (FT3) /自由甲状腺素 (FT4) 比率和TFQIFT3与慢性结核病患者的死亡率有负相关性.
- 卡普兰-梅尔分析揭示了几种甲状腺参数与全因死亡率之间的U形关系,并将心血管死亡率与特定参数之间的U形关系反转.
结论:
- 甲状腺功能和恒温参数与CKD患病率和死亡率有显著的关联.
- 特定的甲状腺指标显示了复杂的,非线性关系与死亡结果在CKD.
- 需要进一步的研究来阐明关联甲状腺健康和病进展的潜在机制.
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