[在老年男性的跨关前列腺活检中使用不同的麻醉剂组合:前性,随机化,受控的单心试验]
Chen-Dong Guo1, Jie Pu1, Yi-Min Hu1,2
1Department of Anesthesiology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213003, China.
Zhonghua nan ke xue = National journal of andrology
|August 10, 2025
概括
雷米马佐拉姆和阿尔芬坦尼尔为接受跨关节前列腺活检的老年男性提供卓越的血液动力稳定性和更快的恢复. 这种组合减少了与基于醇的麻醉相比的不良反应.
科学领域:
- 麻醉学 麻醉学
- 老年医学 老年医学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 甲经前列腺活检是老年男性的常见手术.
- 优化麻醉组合对于患者的安全和康复至关重要.
- 目前的麻醉选择可能呈现出不同的血液动力学和恢复配置文件.
研究的目的:
- 为了比较不同静脉麻醉组合的临床疗效,在老年男性患者中进行跨关节前列腺活检.
- 为了评估血液动力学稳定性,恢复时间和麻醉组间不良事件发生率.
主要方法:
- 132名65岁以上的男性患者被随机分为四组:普罗波+苏芬坦尼尔 (PS),雷米马佐拉姆+苏芬坦尼尔 (RS),普罗波+阿尔芬坦尼尔 (PA) 和雷米马佐拉姆+阿尔芬坦尼尔 (RA).
- 关键指标包括平均动脉压 (MAP),心率 (HR),里士满兴奋镇静量 (RASS) 评分,麻醉后护理单位 (PACU) 停留时间和不良反应.
- 数据是在麻醉诱导期间,手术期间和手术后收集的.
主要成果:
- 基于雷米扎的组 (RA和RS) 与基于普罗波的组 (PA和PS) 相比,对MAP和HR的影响明显较小.
- 在RA和RS组中,注射疼痛的发生率较低,RASS得分较高,表明恢复速度更快.
- 脊髓灰质炎组的呼吸系统抑郁的发病率较高,而RA和RS组有更多的手术内运动和需要救援药物,尽管剂量在各组中相似.
结论:
- 结合雷米马佐拉姆和阿尔芬坦尼尔 (RA) 提供了更稳定的手术内血动力学和更快的恢复与较少的不良反应在老年男性进行跨关节前列腺活检.
- 这种组合可能有利于在手术期间保持自发呼吸.
- 对于管理与针刺相关的运动,可以考虑辅助罗.
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