严重的金黄色葡萄球菌感染:相关因素和结果
Narendra Babu Valobdás1, Marcelo Ribeiro Alves1, Erica Aparecida Dos Santos Ribeiro da Silva1
1Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro, RJ, Brazil.
概括
在巴西的HIV阳性患者中研究了包括MRSA在内的严重金黄色葡萄球菌感染. 虽然年轻,这些患者出现了更多的复发,但死亡率与非艾滋病毒患者相似.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 流行病学 流行病学
背景情况:
- 黄金葡萄球菌,特别是耐甲林黄金葡萄球菌 (MRSA),导致严重的,危及生命的感染,治疗选择有限.
- 这项研究调查了2016年至2021年巴西里约热内卢住院患者的严重金黄色细菌感染情况.
研究的目的:
- 在巴西医院环境中描述严重的金黄色细菌感染.
- 为了比较与艾滋病毒感染者 (PLHIV) 和非艾滋病毒患者之间的临床和人口特征和结果.
- 分析MRSA感染在这个群体中的流行率和特征.
主要方法:
- 用微生物学实验室诊断和医疗记录审查的数据进行回顾性研究.
- 在PLHIV和非HIV患者之间对临床人口统计变量和结果的比较.
- 使用Jamovi 1.6和R 4.0.1软件进行的统计分析.
主要成果:
- 确定了67名患有严重黄金色杆菌感染的患者;46.3%是PLHIV患者,年龄明显较小 (中位数为36岁与60岁).
- 29.9%的感染是MRSA,在社区感染中发生的比例更高 (38.8%). 超过三分之一的PLHIV患者患有MRSA,所有这些患者对西素敏感.
- 在PLHIV和非HIV患者之间,或在MRSA和MSSA组之间,没有观察到死亡率的显著差异. 然而,MRSA细菌病的30天死亡率 (44.4%) 与MSSA细菌病 (10%) 相比较高.
结论:
- 艾滋病毒是严重的黄金色杆菌感染中常见的并发症,PLHIV中MRSA的流行率显著.
- PLHIV患者年轻,死亡率不高,但感染复发率和新的葡萄球菌感染率增加.
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