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Updated: Sep 12, 2025

Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
成年人患短肠综合征导致慢性肠衰竭的发生率:可行性研究
Loris Pironi1, Federica Sacilotto2, Anna Simona Sasdelli2
1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Centre for Chronic Intestinal Failure, IRCCS AOUBO, Bologna, Italy.
这项研究确定了与慢性肠衰竭 (SBS-CIF) 相关的短肠综合征的发生率. 在博洛尼亚,住院发病率为8.9%,人口发病率为每百万居民1.96例.
科学领域:
- 胃肠病学和肝病学
- 外科胃肠道外科手术
- 流行病学 流行病学
背景情况:
- 短肠综合征相关的慢性肠衰竭 (SBS-CIF) 发生率以前是未知的.
- 为了建立调查SBS-CIF发病率的协议,进行了一项可行性研究.
- 这项研究旨在确定SBS-CIF的住院和基于人口的发病率.
研究的目的:
- 测试一种用于调查SBS-CIF的发病率的协议.
- 为了确定SBS-CIF.的住院发病率.
- 为了确定博洛尼亚大都会地区SBS-CIF的人口发病率.
主要方法:
- 在两个手术单位进行了为期3个月的回顾性调查.
- 纳入标准:成年人 (≥18岁) 经过小肠切除并没有先前的家庭亲肠营养 (HPN).
- 诊断SBS-CIF:在手术后3个月内在HPN上出院;发病率根据医院出院和大都市人口计算.
主要成果:
- 67名患者符合纳入标准.
- 在医院的SBS-CIF发病率为8.9% (在67名在HPN上出院的6名患者中).
- 博洛尼亚的人口发病率为每10^6居民1.96例.
结论:
- 该研究提出了一个可行的模型来调查成人SBS-CIF发病率.
- 提供SBS-CIF的初始流行病学数据,这是一个研究不足的领域.
- 为未来在国家和国际范围内进行多中心研究提供了一个模型.
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