基于肉酸的非溶剂凝贴片用于通过皮肤递送药物
Xi-Xi Xiang1, Qing-Chang Xia1, Xiao-Bin Zhang1
1Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Journal of advanced research
|August 10, 2025
概括
一种新型的非溶剂凝系统有效地加载不溶于水的药物,以控制通过皮肤递送. 这种创新的凝贴片显示出治疗心肌缺血和愈合伤口的前景,提供了可扩展的生物医学应用.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
背景情况:
- 聚合物网络在生物应用中至关重要,但通常需要复杂的基于溶剂的药物加载.
- 传统方法面临着诸如繁的程序,密集的化学设计和溶剂损失引起的老化等挑战.
- 提出了一种新的非溶剂凝系统,以克服药物加载和透皮释放的这些局限性.
研究的目的:
- 开发一种非溶剂的通过皮肤凝贴片,用于加载肉酸 (CA).
- 评估凝贴在治疗心肌缺血 (MI) 和促进伤口愈合方面的疗效.
- 为了研究凝的特性和通过皮肤递送药物的能力.
主要方法:
- 通过化CA,硫酸乙酸 (TA) 和乙酸二水合物,合成了非溶剂的透皮凝贴片.
- 标志着凝的特性,包括化学结构,机械强度,胀,,粘附和抗菌活性.
- 评估了体外和体内生物相容性,并使用HPLC量化了通过皮肤释放的CA. 在MI和伤口愈合的老鼠模型中验证了治疗效果.
主要成果:
- 凝贴片表现出物理和化学交叉连接,证明了柔性,粘性弹性和自我愈合特性.
- 获得显著的组织粘附强度 (0.12 MPa) 和受控的通过皮肤释放CA (20-40 μg/h).
- 组织学分析证实了凝能够修复心肌损伤,促进血管生成,并抑制MI模型中的缩.
结论:
- 这项研究提出了一种新的非溶剂凝贴方法,用于通过皮肤递送药物.
- 开发的凝系统对大规模生产和各种生物医学应用具有前景.
- 这些发现突出了克服装载和运送水不溶性药物的挑战的新战略.
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