六价暴露会诱导免疫失调和肺组织中性细胞细胞外陷的形成
Zhiqiang Ji1, Zekang Su2, Changmao Long3
1Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, 100191, China.
概括
吸入六价 (Cr(VI)) 暴露会导致免疫系统损伤和炎症,特别是在肺部. 这些影响在小鼠的两周康复期后是可逆的.
科学领域:
- 环境健康 环境健康
- 免疫毒理学 免疫毒理学
- 职业健康 职业健康 职业健康
背景情况:
- 六价 (Cr(VI)) 是一种已知的人类致癌物,与环境污染有关.
- 暴露于Cr (VI) 的免疫毒性作用和炎症机制尚未完全理解.
研究的目的:
- 在模拟的职业环境中调查Cr (VI) 吸入的免疫毒性和炎症反应.
- 探索免疫失调和由Cr{(VI) 诱导的炎症之间的关系.
主要方法:
- 使用小鼠动态吸入暴露系统来模仿职业Cr (VI) 暴露.
- 进行了多器官免疫评估和肺组织炎症分析.
- 分析了淋巴细胞子集,细胞因子水平,中性粒细胞外细胞陷 (NETs) 形成和炎症酶激活.
主要成果:
- 吸入Cr(VI) 导致淋巴细胞子集的时间依赖性变化和免疫细胞因子激素的升高.
- 暴露触发了NETs的形成和肺组织中的炎症酶激活.
- 免疫失调与NETs形成和炎症酶激活有很强的相关性.
结论:
- 暴露于Cr(VI) 诱导免疫功能障碍和炎症,其特征是NETs和炎症酶激活.
- 两周的恢复期显著改善了Cr (VI) 诱导的免疫和炎症变化.
- 这些发现突显了在Cr (VI) 职业暴露中免疫功能障碍和炎症之间的相互作用.
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