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结直肠癌中的循环瘤DNA甲基化:一个元分析
Zhipeng Pan1, Guoqing Li2, Hanqing Wu2
1Department of Medical Oncology, the second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
概括
循环瘤DNA (ctDNA) 甲基化显示了对结直肠癌 (CRC) 查的高准确性. 将ctDNA甲基化与癌胚抗原 (CEA) 结合起来,进一步提高了CRC的诊断性能.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 生物标志物发现发现
背景情况:
- 结肠直肠癌 (CRC) 仍然是一个重大的全球健康挑战.
- 早期检测对于改善患者的治疗结果和生存率至关重要.
- 循环瘤DNA (ctDNA) 甲基化正在成为癌症检测的有希望的生物标志物.
研究的目的:
- 系统地评估ctDNA甲基化对结直肠癌 (CRC) 的诊断准确性.
- 评估单独ctDNA甲基化和与其他生物标志物结合的性能.
- 确定影响ctDNA甲基化试验诊断功效的因素.
主要方法:
- 对已发表的研究进行了全面的元分析.
- 综合了来自147篇文章的数据,其中包括15,133名CRC患者.
- 计算了聚合的灵敏度,特异性,诊断几率比率 (DOR) 和AUC.
主要成果:
- ctDNA甲基化显示,聚合灵敏度为0.655,特异性为0.902,AUC为0.8851.
- 将ctDNA甲基化与癌胚抗原 (CEA) 结合起来,改善了AUC至0.9269.9.
- 多基因面板和数字PCR测定显示出卓越的诊断价值.
结论:
- ctDNA甲基化对早期CRC检测和查具有显著的诊断准确性.
- 与CEA结合,可以提高诊断性能,这表明它具有临床效用.
- 需要进一步的研究来解决在广泛临床应用之前的剩余问题.
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X-chromosome...