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慢性创伤性脑病的近期进展

Katharine J Babcock1, Bobak Abdolmohammadi1, Ann C McKee2

  • 1Alzheimer's Disease Research Center and Chronic Traumatic Encephalopathy Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts; Departments of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.

The American journal of pathology
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概括

重复的头部冲击 (RHIs) 可以导致慢性创伤性脑病变 (CTE),这是一个经死后诊断的神经退行性脑病变. CTE涉及独特的蛋白积累,风险随着接触运动中暴露时间的增加而增加.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经病理学神经病理学
  • 运动医学 运动医学

背景情况:

  • 重复的头部冲击 (RHIs) 与慢性创伤性脑病 (CTE) 相关,这是一种进展性神经退行性脑病.
  • 目前,CTE只能通过死后的神经病理学检查来诊断.
  • 脑脊髓炎的特征性病变涉及高酸化的周血管积累,特别是在皮层硫深处.

研究的目的:

  • 阐明CTE的神经病理特征和生物力学基础.
  • 探索RHI暴露与CTE风险和严重程度之间的关系.
  • 调查RHI与其他神经退行性蛋白质病变的相关性.

主要方法:

  • 对CTE的神经病理发现的审查.
  • 对与RHI相关的生物力学力量的分析.
  • 在运动员中检查RHI暴露和CTE之间的剂量反应关系.
  • 评估与其他蛋白质聚合物的共同病理.

主要成果:

  • CTE病理的特点是独特的分子结构,模式和分布.
  • 多年接触体育运动和CTE风险/严重程度之间存在剂量反应关系.
  • 此外,RHIs还促进β-粉样蛋白,α-synuclein和TDP-43的沉积,增加其他神经退行症的风险.

结论:

  • 慢性脑脊髓炎是一种由RHIs引起的独特病,诊断需要进行尸体分析.
  • RHIs的生物力学,特别是硫中的旋转力,有助于病理.
  • 暴露于RHI可能会使个体易患CTE以外的一系列神经退行性疾病.