在OncoTrace-TOO:可解释的机器学习框架,用于使用转录密码签名识别癌症组织的起源
Yang Hao1,2,3, Haochun Huang3,4, Daiyun Huang3
1Hepatobiliary and Pancreatic Surgery, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, China.
Cancer reports (Hoboken, N.J.)
|August 10, 2025
概括
通过基因表达,OncoTrace-TOO精确地分类癌症组织的起源,为改善未知的原发性癌症的诊断和治疗提供生物可解释的见解.
科学领域:
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
- 机器学习 机器学习
背景情况:
- 未知原发性癌症 (CUP) 是一个重大的诊断挑战,限制了向治疗的选择.
- 目前用于瘤起源识别的机器学习和转录学方法往往缺乏解释性,并与类似的瘤类型作斗争.
研究的目的:
- 开发一个透明和生物可解释的机器学习框架,用于准确的癌症组织起源 (TOO) 分类.
- 为了促进临床诊断和改善CUP的治疗策略.
主要方法:
- 开发了OncoTrace-TOO,一种使用基因表达特征的新型原生组织分类模型.
- 通过一对其余差异性表达分析识别的采用泛癌歧视性分子特征.
- 使用后勤回归作为分类算法.
主要成果:
- 在OncoTrace-TOO的总体准确度为0.967,对7种癌症类型进行了完美的分类.
- 在TCGA和GEO验证数据集上对原发性癌症和转移性癌症均表现出高的预测准确性.
- 在独立的临床样本上表现出更强的能力来解决组织学上类似的恶性瘤,并对罕见的亚型进行分类,准确度为0.857.
结论:
- 在OncoTrace-TOO提供高预测准确度的起源组织分类和生物学上有意义的见解.
- 该框架支持临床决策,承诺在具有挑战性的癌症病例中提高诊断精度.
- 提供了指导瘤学个性化治疗策略的潜力.
更多相关视频
相关概念视频
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
8.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.0K
02:21Cancers Originate from Somatic Mutations in a Single Cell
12.7K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
12.7K
01:33Cancer-Critical Genes I: Proto-oncogenes
9.1K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.1K