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在泌尿癌中进行液体活检检测:专注于尿液
Pasquale Pisapia1, Francesco Pepe1, Gianluca Russo1
1Department of Public Health, University of Naples Federico II, Naples, Italy.
Urologic oncology
|August 10, 2025
概括
尿液分析为尿道癌症的液体活检提供了一种有价值的非侵入性方法. 本综述探讨了用于管理这些恶性瘤的尿液生物标志物,解决当前的挑战和未来的潜力.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
背景情况:
- 液体活检彻底改变了泌尿癌的治疗方法.
- 瘤核酸和分析物的替代来源至关重要.
- 尿液成为血液液体活检的重要替代品.
研究的目的:
- 审查尿液生物标志物分析在泌尿病恶性瘤中的应用.
- 突出将尿液活检整合到临床实践中的挑战.
- 讨论以尿为基础的诊断的未来前景.
主要方法:
- 对尿路癌症尿液生物标志物分析的当前文献的综述.
- 分析尿液作为与血相补充的分子资源.
- 确定临床整合的挑战和未来方向.
主要成果:
- 尿液作为一种天然的超离心机,产生有价值的分子信息.
- 尿液生物标志物分析显示,在治疗泌尿系统恶性瘤方面具有显著的潜力.
- 整合到临床实践中面临挑战,但有希望.
结论:
- 尿液是尿道癌症扩大液体活检概念的重要组成部分.
- 需要进一步的研究来克服挑战,并充分实现临床效用.
- 尿液生物标志物分析为癌症管理提供了一个有希望的,非侵入性的途径.
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