功能和内化障碍与心脏代谢和免疫相关疾病在家庭内协同聚集:基于人口的队列研究
Olivier D Steen1, Martje Bos2, Sonja L van Ockenburg3
1Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, Netherlands. o.d.steen@umcg.nl.
BMC medicine
|August 10, 2025
概括
功能和内化障碍与免疫和心脏代谢疾病有共同的家族风险. 这表明共同的潜在风险因素可能会影响这些疾病,指导未来的研究和治疗开发.
科学领域:
- 遗传学和流行病学
- 精神病学和免疫学 精神病学和免疫学
- 复杂疾病病因学 复杂疾病病因学
背景情况:
- 功能障碍 (FD) 和内化障碍 (ID) 与心脏代谢和免疫疾病具有共同的家族风险和并发症.
- 了解这些疾病的家族聚合对于阐明FD和ID的病因至关重要.
- 生命线队列研究提供了大量基于人口的数据集,用于调查这些复杂的关系.
研究的目的:
- 调查功能障碍 (肌痛性脑筋炎/慢性疲劳综合征,纤维肌痛,易怒性肠综合征) 和内化障碍 (严重抑郁症,泛性焦虑症) 与心脏代谢和免疫相关疾病的家族共同聚合.
- 为了深入了解这些疾病背后的共同病因因素.
- 用复发风险比率和家族相关性来评估家族风险.
主要方法:
- 利用了166,774名参与者在基于人口的生命线队列研究中的数据.
- 针对三个FD (ME/CFS,纤维肌痛,IBS) 和两个ID (MDD,GAD) 的确定的病例.
- 分析了心脏代谢疾病 (肥胖,MASH,T2D,高血压,心血管疾病) 和与免疫相关的疾病 (自身免疫性疾病,亚托皮).
- 使用模型流行率的后勤回归和计算的复发风险比率 (λR) 和家族相关性 (rf) 来评估共同聚合.
主要成果:
- 所有研究的功能和内化障碍都显示出与免疫相关疾病的家族共同聚合 (λR范围为1.06-1.24).
- 肌痛性脑筋炎/慢性疲劳综合征,纤维肌痛和严重抑郁症与大多数心脏代谢疾病 (λR范围为1.00-1.23) 共同聚集.
- 在两个疾病组中,ME/CFS,纤维肌痛和MDD的家族相关性模式 (rf范围为0.12-0.44) 类似,而IBS和GAD显示出更可变的模式.
结论:
- 功能性和内化性疾病与免疫相关和心脏代谢性疾病都有显著的家族风险.
- 这些发现表明,与心脏代谢和免疫疾病相关的病因因素也可能在功能障碍的发展中发挥作用.
- 未来的研究应该专注于识别这些共同的风险因素,以开发功能障碍的新疗法目标.
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