白色脂肪组织色的多方面的调节及其治疗潜力
Abhishek Satheesan1, Janardanan Kumar2, Kakithakara Vajravelu Leela1
1Department of Microbiology, SRM Medical College Hospital and Research Centre, SRMIST, Chengalpattu, Kattankulathur, Tamil Nadu, 603203, India.
Journal of physiology and biochemistry
|August 10, 2025
概括
脂肪组织棕色化将白色脂肪转化为棕色/色脂肪,有助于治疗肥胖和代谢障碍. 本综述探讨了其调节,对代谢健康的影响以及治疗潜力,包括饮食,运动和新型基因疗法.
科学领域:
- 代谢生理学 代谢生理学
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 白色脂肪组织 (WAT) 色是能量消耗和代谢健康的关键机制.
- WAT棕色的失调与肥胖和相关的代谢障碍有关.
- 了解WAT棕色化转录和表观遗传调节对于治疗开发至关重要.
研究的目的:
- 审查白色脂肪组织 (WAT) 色的转录和表观遗传调节.
- 探索WAT棕色化对代谢健康的影响及其在疾病中的作用.
- 讨论外部因素,肠道微生物群和治疗策略对WAT色的影响.
主要方法:
- 对转录和表观遗传机制的文献综述.
- 分析UCP1基因和线粒体动态的作用.
- 检查饮食,运动和肠道微生物组组成的影响.
- 审查当前和新兴的制药,营养药和基因疗法.
主要成果:
- WAT棕色受复杂的转录和表观遗传网络的调节.
- UCP1基因和线粒体功能是热生成的核心.
- 饮食,运动和肠道微生物组合显著调节WAT棕色化.
- 各种治疗药物和基因疗法在诱导WAT色方面表现有前途.
结论:
- 在肥胖和代谢障碍方面,WAT棕色化是一个有前途的治疗点.
- 需要进行进一步的研究,包括临床试验,以克服个人变异性和长期安全性等挑战.
- 针对新途径的个性化治疗策略对于有效治疗至关重要.
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