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在慢性腰部疼痛中,周水道灰色分支的功能连接受到干扰

Cuiping Mao¹, Bo Zhang², Minmin Guo²

¹Department of Radiology, Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, 710004, Shaanxi, China. cp.mao@xjtu.edu.cn.

Brain imaging and behavior

|August 10, 2025

概括

慢性腰部疼痛涉及到大脑连接的变化,在水道灰色 (PAG) 和相关区域. 这些变化影响疼痛和注意力,与患者的抑郁和疾病持续时间相关.

科学领域:

神经科学是一个神经科学.
疼痛研究疼痛研究
肌肉骨系统疾病肌肉骨系统疾病

背景情况:

慢性腰部疼痛 (cLBP) 是一个普遍的全球健康问题.
周水管灰 (PAG) 涉及疼痛调节,但其子部分在cLBP中的具体作用尚不清楚.

研究的目的:

为了研究cLBP患者的PAG分类中的功能连接性改变.
为了将神经成像发现与临床措施 (如抑郁症和疾病持续时间) 相关联.

主要方法:

在75名cLBP患者和75名健康对照中使用休息状态功能连接 (rsFC) 和基于任务的fMRI.
分析了PAG分区的连接性,特别是腹侧PAG (vlPAG).

主要成果:

在cLBP患者中,vlPAG和后中心/上顶叶之间的rsFC增强.
在cLBP患者中,观察到侧向PAG和前皮/后皮带皮层之间的rsFC降低.
基于任务的fMRI揭示了cLBP患者的背部中间前额叶皮质,小脑,前中心,后中心的vlPAG连接性发生变化.

结论:

研究结果表明,cLBP中通过PAG-somatosensory皮质途径中断了下降疼痛调制.
在cLBP中,通过vlPAG通路 (vlPAG-dmPFC,vlPAG-PreCG/PoCG) 的注意力调节受损.
改变的PAG功能连接性与临床症状有关,突出其在cLBP病理生理学中的作用.

关键词:

慢性下背部疼痛慢性下背部疼痛中部前额叶皮层中部前额叶皮层.多源干扰任务多源干扰任务周边水道灰色水道灰色休息状态的功能连接.

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