基于多脊椎CT的有限元模型可以准确预测菌株吗? 一个体外验证研究
Alessandra Aldieri1, Chiara Garavelli2, Luca Patruno3
1PolitoBIOMedLab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Torino, Italy.
概括
脊椎的有限元素 (FE) 模型需要更好的椎间盘材料特性. 目前基于CT的模型准确地预测了脊椎位移,但与磁盘应变作斗争,需要新的建模方法来提高准确性.
科学领域:
- 生物力学 生物力学
- 计算建模计算建模
- 脊柱研究研究 脊柱研究
背景情况:
- 目前用于脊椎骨折风险的有限元素 (FE) 模型通常分析单个脊椎,忽视了脊椎间盘在负载分配中的作用.
- 将脊椎间盘纳入多脊椎FE模型可以实现更现实的边界条件.
- 计算机断层扫描 (CT) 扫描提供了脊椎材料属性,但缺乏磁盘信息.
研究的目的:
- 仅使用CT数据开发脊椎的多级FE模型.
- 通过将预测的移位和应变与实验测量进行比较来验证这些模型.
- 评估不同椎间盘材料特性对模型准确性的影响.
主要方法:
- 人类T10-L1脊柱段在曲-压缩中进行了测试.
- 数字图像相关性测量了测试期间的表面位移和应变.
- 创建了一个基于CT的FE模型,将基于HU的属性分配给脊椎,并将各种超弹性属性分配给磁盘组件 (核脉,纤维结节).
主要成果:
- 该FE模型准确地预测了脊椎表面位移 (R2 = 0.92-0.99).
- 然而,不同的磁盘构成定律导致与实验数据相比,预测的主要菌株分布存在显著差异 (平均相对误差超过34%).
结论:
- 基于CT的多层次FE模型可以准确预测脊椎位移.
- 目前在这些模型中建模椎间盘材料属性的方法不足以准确预测应变.
- 对椎间盘进行修订的建模策略对于提高基于CT的多级FE模型的准确性至关重要.
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