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Hongbo Shi¹, Meitao Wu¹, Xiaoliang Wu¹

¹College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.

|August 11, 2025

概括

肠道微生物及其代谢物与动脉样硬化 (AS) 有关. 特定的微生物属显示出作为AS诊断的非侵入性生物标志物的潜力,并可能提供治疗点.

科学领域:

微生物学微生物学
基因组学就是基因组学.
心血管研究研究心血管研究

背景情况:

动脉样硬化 (AS) 是心血管疾病的主要原因,肠道微生物群失调发挥着重要作用.
在AS病变发生过程中,微生物与宿主相互作用的确切机制尚未完全理解.
现有研究面临的局限性是由于方法上的不一致性和缺乏对AS的定义微生物特征.

研究的目的:

通过综合的多组学分析来描述动脉样硬化 (AS) 中肠道微生物组的功能特征.
确定与AS相关的微生物-代谢物-宿主基因相互作用.
评估肠道微生物种群作为AS非侵入性生物标志物的诊断潜力.

主要方法:

对6个公共AS微生物组数据集和8个外围血液宿主转录组数据集的综合分析.
使用元基因组和16S rRNA基因测序进行微生物分析.
微生物代谢潜力的计算推断和代谢物与宿主基因相互作用的预测.

主要成果:

确定了五种"微生物-代谢物-宿主基因"关联,涉及特定的微生物属,代谢物 (乙醇,H2O2) 和宿主基因 (FANCD2,GPX2).
五种微生物属显示出强大的诊断潜力,作为AS的非侵入性生物标志物,通过交叉验证和转移验证进行验证.
与高血压,炎症性肠道疾病 (IBD),糖尿病和肥胖症的队列相比,生物标志物特异性得到证实.

结论:

肠道微生物组的功能特征与AS宿主基因相互作用,提供了对AS病原学的见解.
特定的肠道微生物种类显示出作为AS的非侵入性诊断生物标志物的希望.
肠道微生物群代表了动脉样硬化 (AS) 的潜在治疗点.

关键词:

动脉样硬化是一种动脉样硬化.诊断生物标志物的生物标志物我们的肠道微生物组.宿主转录组的转录组是什么?多种主题的多种主题.

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