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Updated: Sep 12, 2025

Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry
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Published on: October 24, 2018

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高性能本地分离mAb蛋白质形式的CZE-MS在本地和变质纳米ESI条件下超敏感电荷变体表征

Ann-Katrin Schwenzer1, Christian Neusüß1

  • 1Faculty of Chemistry, Aalen University, Beethovenstraße 1, Aalen 73430, Germany.

Analytical chemistry
|August 11, 2025
PubMed
概括

一种新的毛细管区电泳质谱法 (CZE-MS) 方法使治疗单克隆抗体 (mAb) 电荷变异的详细表征成为可能. 这种技术可以对蛋白质形式进行敏感的识别,这对于生物制药质量控制至关重要.

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