0天至3岁的丹麦儿童血中电离的参考范围,使用实验室注册数据
Anne-Sofie Allermann Faarvang1,2, Thomas S Rosengren1, Lars E Pedersen1
1Department of Clinical Biochemistry, Næstved Slagelse Ringsted Hospitals, Slagelse, Region Zealand, Denmark.
Clinical chemistry and laboratory medicine
|August 11, 2025
概括
这项研究确定了儿科血中电离的新参考范围,显示出出生后的升高和随后的下降,这对于准确评估婴儿的代谢至关重要.
科学领域:
- 临床化学 临床化学
- 儿科内分泌学 儿科内分泌学
- 生物标记分析 生物标记分析
背景情况:
- 电离的测量对于评估代谢至关重要.
- 在儿科患者群体中确定电离的准确参考范围是具有挑战性的.
- 当前的参考范围可能无法充分反映幼儿的生理变异.
研究的目的:
- 在儿科人口 (0-3岁) 中为血电离建立新的,准确的参考范围.
- 为改善婴儿和幼儿代谢的临床评估提供最新数据.
- 分析生命早期电离水平的趋势.
主要方法:
- 在2012年至2023年期间,对来自16039名儿童 (0-3岁) 的20,516个电离测量的回顾性分析.
- 排除来自重症监护/科的样本和具有极端pH值 (<7.2或>7.6) 的样本.
- 建立pH校正和非校正的参考范围,每月一次测量每名儿童,用于重复采样.
主要成果:
- 建立了血电离的新参考范围,按年龄组分层.
- 在生命的前10天观察到显著的变化,水平在第八天左右达到顶峰.
- 电离水平在第八天后逐渐下降,在18-24个月之间稳定.
结论:
- 这项研究为儿科患者的血电离提供了新的,准确的参考范围.
- 出生后血电离的生理上升,随后下降得到证实.
- 这些发现有助于精确解释幼儿的电离水平.
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