高血压家族史预测女性甲状腺癌风险:以整合机器学习和基因组分析为基础的基于人口的横截面研究
Zijin Wang1, Yanhui Lin2, Fanke Meng3
1The Second Clinical Medicine School, Southern Medical University, Guangzhou, Guangdong, China.
Cancer medicine
|August 11, 2025
概括
血压高的家族史显著增加了女性甲状腺癌的风险. 这一发现得到了遗传分析的支持,这表明将高血压查与遗传特征进行整合,以进行个性化的甲状腺癌管理.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 甲状腺癌是一种常见的内分泌恶性瘤,女性的发病率更高.
- 怀孕引起的高血压是已知的危险因素,但与甲状腺癌的联系尚不清楚.
- 这项研究调查了高血压家族史和甲状腺癌风险之间的性别特异关联.
研究的目的:
- 为了探索高血压和甲状腺癌的家族病史之间的性别特异关系.
- 确定与甲状腺癌风险相关的临床和遗传因素.
- 评估甲状腺癌管理中综合查和基因分析的潜力.
主要方法:
- 一项大规模的横截面研究,在中国对52,963名参与者进行了研究,其中包括296例甲状腺癌病例.
- 利用可解释的集体机器学习模型来评估风险因素和赔率比率 (OR).
- 采用Cox比例危险和Kaplan-Meier分析来确定与高血压相关的基因和生存结果.
主要成果:
- 血压高血压的家族病史与甲状腺癌率的变化有显著联系 (p < 0.001).
- 患有高血压家族史的女性显示甲状腺癌风险增加 (OR = 1.53,p = 0.04),这是一个关键预测因素.
- 基因分析显示FOXD3,F10和SLC12A5是关键基因,与较差的生存率和独特的免疫特征有关.
结论:
- 患有高血压的家族史是甲状腺癌的重要风险因素,特别是在女性中.
- 对高血压相关基因的基因分析可能会改善甲状腺癌风险分层.
- 将高血压查与遗传数据相结合,可以为个性化管理策略提供信息.
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