功能梯度的性别差异和ASD学龄前儿童的动态功能连接
Guangrong Wu1, Linfeng Song1, Guomin Zhang1
1Department of Radiology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China.
CNS neuroscience & therapeutics
|August 11, 2025
概括
自闭症谱系障碍 (ASD) 显示了幼儿大脑网络组织的性别差异. 这些发现突出了自闭症的复杂性,并为其神经成像机制提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 生物医学工程 生物医学工程
背景情况:
- 自闭症谱系障碍 (ASD) 的患病率在男性中较高,但其病因不明.
- 在ASD的学龄前儿童中,研究大脑网络组织中的性别差异至关重要.
研究的目的:
- 为了检查ASD的学龄前男孩和女孩的多层次大脑网络重组.
- 评估这些网络差异对临床症状的影响.
- 探索性特异的神经成像机制在ASD.
主要方法:
- 使用功能梯度分析和动态功能连接.
- 在54名ASD儿童和44名典型发育 (TD) 儿童 (2-6岁) 中比较了大脑功能网络.
- 机器学习模型评估了分类性能,以区分ASD和TD.
主要成果:
- 自闭症组在多个大脑网络中表现出功能梯度异常.
- 患有自闭症的男孩在注意力,边缘和默认模式网络 (DMN) 中表现出异常.
- 患有自闭症的女孩主要在DMN中表现出初级异常,具有明显的二次和第三梯度模式.
结论:
- 在 ASD 的学龄前儿童的功能梯度和动态功能连接方面存在显著的性别差异.
- 这些发现强调了自闭症的异质性,并为了解其神经成像基础提供了一个新的框架.
相关概念视频
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