相关实验视频

Updated: Sep 11, 2025

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

Published on: January 13, 2023

喉状细胞癌的一个新的正位素小鼠模型

Junrong Wang¹, Ming Song¹, Lei Wang¹

¹Department of Otorhinolaryngology Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, China.

|August 11, 2025

概括

研究人员开发了一种用于喉癌研究的新型 ортотоп性小鼠模型. 这种模型准确地模仿了人类的免疫反应和瘤的发展,有助于未来的研究.

科学领域:

在瘤学瘤学.
翻译研究是翻译研究.
免疫学免疫学免疫学

背景情况:

喉癌研究需要有效的临床前模型.
现有的模型可能无法完全回顾人类疾病的微环境.

研究的目的:

为了建立一个新的和可重复的喉癌的 ортотоп性小鼠模型.
促进对喉癌机制的深入研究.

主要方法:

在C57BL/6小鼠的喉中植入Meer-LUC状细胞癌细胞.
使用MRI和3D光学成像监测瘤生长和存活率.
喉和淋巴结组织的组织病理学分析.
患者瘤的单细胞测序,形模型和皮下模型,以分析免疫微环境.

主要成果:

成功建立了15个在位喉癌小鼠模型.
观察到持续的瘤生长,由组织病理学证实.
单细胞测序表明,与皮下模型相比,正体模型更好地模拟喉癌免疫微环境.

结论:

已经开发出一种新的,可复制的喉癌的正位点小鼠模型.
该模型忠实地模仿了人类的免疫反应和瘤的生物进化.
这种模型是研究喉癌分子机制的关键框架.

关键词:

免疫微观环境免疫微环境喉皮状细胞癌瘤一个对象型的鼠标模型.

更多相关视频

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

相关概念视频

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...